(Download) "Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease (Minireview)" by Clinical Chemistry ~ Book PDF Kindle ePub Free
eBook details
- Title: Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease (Minireview)
- Author : Clinical Chemistry
- Release Date : January 01, 2000
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 183 KB
Description
For many years, the bile pigment bilirubin was considered a toxic waste product formed during heme catabolism. However, more recent evidence suggests that bilirubin is a potent physiological antioxidant that may provide important protection against atherosclerosis, coronary artery disease (CAD), and inflammation. It is generally accepted that oxidative reactions are involved in the pathophysiology of these disease processes. Substantial evidence has documented that the development of CAD involves lipid oxidation and formation of oxygen radicals and that atherosclerosis and inflammation are associated with formation of oxygen and peroxyl radicals (1-3). The antioxidant capacity of bilirubin and its ability to provide potent scavenging of peroxyl radicals have led to suggestions that mildly increased circulatory bilirubin may have a physiologic function to protect against disease processes that involve oxygen and peroxyl radicals.