(DOWNLOAD) "Association of Increased Ferritin with Premature Coronary Stenosis in Men (Lipids, Lipoproteins, And Cardiovascular Risk Factors)" by Clinical Chemistry * eBook PDF Kindle ePub Free
eBook details
- Title: Association of Increased Ferritin with Premature Coronary Stenosis in Men (Lipids, Lipoproteins, And Cardiovascular Risk Factors)
- Author : Clinical Chemistry
- Release Date : January 01, 2001
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 216 KB
Description
The established risk factors of coronary artery disease (CAD) [4], such as age, male sex, high serum cholesterol, smoking, hypertension, and glucose intolerance, do not account for the overall risk of CAD (1). Therefore, it has been hypothesized that the assessment of novel markers helps to identify persons prone to premature atherosclerosis. Age- and sex-related increases in iron stores have been linked to the pathogenesis of several common diseases, including atherosclerosis (2). Iron stores increase to concentrations above the physiologic requirements with aging, and such increased concentrations have been implicated in the pathogenesis of atherosclerosis. Interest in this hypothesis is stimulated by its capacity to explain the sex difference in atherosclerotic diseases and the option of preventive lowering of iron stores by repeated phlebotomy. Iron catalyzes the formation of reactive oxygen species through the Fenton and Haber-Weiss reactions (3). Free radicals cause lipid peroxidation, leading to the modification of LDL at the molecular level, facilitating its deposition and leading to the formation of atherosclerotic plaque (4). Divergent information is available on the relationship between body iron stores and CAD. It has been shown that the concentrations of body iron stores are a strong predictor of CAD in eastern Finnish, men (5). Routine voluntary blood donation is associated, epidemiologically, with reduced coronary risk (6, 7). Salonen et al. (8) phlebotomized men over age 50 to reduce their body iron stores and demonstrated significantly decreased susceptibility of LDL to ex vivo oxidation. Furthermore, Kiechl et al. (9) found a highly significant correlation between serum ferritin concentration and pathologic carotid artery wall thickening in a longitudinal cohort study. However, several epidemiologic studies investigating the association between high body iron stores and risk of cardiovascular disease in humans have not provided positive results (10-15).